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Symbol
Name
ID

Malt1
MALT1 paracaspase
MGI:2445027

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased lymphocyte proliferation in response to anti-CD3	Absent isohemagglutinin level	Complete or near-complete absence of specific antibody response to tetanus vaccine	Abnormal lymphocyte count	Recurrent aphthous stomatitis	Skin rash	Immunodeficiency	Recurrent bacterial infections	Recurrent lower respiratory tract infections	Recurrent viral infections
Disease(s) Associated with MALT1
immunodeficiency 12

Mouse Phenotypes

abnormal T cell proliferation

decreased T cell proliferation

abnormal B cell differentiation

abnormal T cell differentiation

abnormal double-negative T cell morphology

absent B-1a cells

abnormal spleen marginal zone morphology

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal immune system morphology

abnormal dendritic cell physiology

impaired humoral immune response

decreased interleukin-2 secretion

Availability

Mouse Genotype

Malt1^m1Btlr/Malt1^m1Btlr

Malt1^m2Btlr/Malt1^m2Btlr

Malt1^m3Btlr/Malt1^m3Btlr

Malt1^tm1Mak/Malt1^tm1Mak

Malt1^tm1Vmd/Malt1^tm1Vmd

Malt1^m1Btlr/Malt1⁺

Malt1^m2Btlr/Malt1⁺

Malt1^m3Btlr/Malt1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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